B12 and folate relationship problems

A Study of the Prevalence of Serum Vitamin B12 and Folic Acid Deficiency in Western Maharashtra

b12 and folate relationship problems

of supplemental folic acid per day. More than this can cause symptoms of vitamin B12 deficiency. This may lead to nervous system problems and eventually. What relationship do vitamin B12 and folic acid share? grave symptoms, such as anemia, depression, stomach and/or intestinal problems and weight loss. 2. To correlate the symptoms with serum vitamin B12 and folic acid levels. [1] stated that there is no relation between hematological and neurological.

However, only the tropical illness responded to yeast extract. Furthermore, although purified liver extract had proved effective in the treatment of pernicious anemia, it did not cure the tropical form 6. This hypothesis was subsequently verified.

Vitamin B12 And Folic Acid | Dr. Schweikart

However, the identification of vitamin B as the anti—pernicious anemia factor in liver 7 followed the isolation of folic acid from yeast 8 by several years, during which time folic acid was administered in large doses to patients with pernicious anemia 9.

Because the inappropriateness of this treatment quickly became apparent, reports of cases thus treated in the late s and early s comprise the entire body of literature on the effect of folic acid administration on persons deficient for vitamin B 10 — Reviews of the historic case reports allude to rapid neurologic deterioration after improvement of anemia 10 Consequently, the idea has developed that excessive intake of folic acid can obscure or mask vitamin B deficiency and potentially delay its diagnosis until neurologic consequences become irreversible Food folic acid fortification and the debate on folic acid safety The move by the United States and other governments to fortify staple food products with folic acid for the prevention of neural tube defects rekindled the debate over the safety of folic acid for the elderly, who are at high risk of vitamin B deficiency.

b12 and folate relationship problems

The high degree of uncertainty led some to question the safety of fortification 1920 and inspired others to criticize the upper intake as too conservative 21 Particularly in light of continued demands for a higher level of fortification 2324clearly defining the benefits and risks of high folic acid intake assumes vital importance. Writing about this challenge, Moore 25 observed that the current fortification program provides the perfect opportunity for epidemiologic study of the unanswered questions, including those related to the interaction between folate and vitamin B Folate status and intake in the era of folic acid fortification Mandatory folic acid fortification of enriched cereal grain products sold in the United States officially took effect in January Vitamin B12 has a vital role in cell growth and development through many reactions and processes that occur in the body.

When the level becomes elevated or lower than the normal, the whole process will collapse because each process is linked to another. Deficiencies can be treated by increasing their consumption in diet or by supplement intake.

Vitamin B6 - Deficiencies & Amazing Benefits

Deficiency, folate, folic acid, metabolism, vitamin B12 How to cite this article: The metabolic processes of folic acid and Vitamin B12 deficiency. J Health Res Rev ;1: They cannot be synthesized in sufficient amount by the human body, and therefore must be obtained from the diet.

Thirteen different types of vitamins are known that are classified by their biological and chemical activity; each one of them has a specific role in our body. The water-soluble vitamins easily dissolve in water and are excreted from the body rapidly since they are not stored for a long time, except for vitamin B As they are stored for a long time, they can lead to hypervitaminosis more than the water-soluble vitamins; some vitamins are vital for the body cell growth and development e.

Folic acid is known as vitamin B9 which has vital functions. Our body needs folic acid for the synthesis, repair, and methylation of DNA.

Vitamin B12 And Folic Acid

Folate has an important role in cell division and it is especially needed during infancy and pregnancy. Human body requires folate in order to produce healthy red blood cells and prevent anemia, while vitamin B12 plays an important role in supplying essential methyl groups for protein and DNA synthesis. Vitamin B12 is bound to the protein in food and hydrochloric acid in the stomach releases B12 from protein during digestion.

Once released, B12 combines with a substance called intrinsic factor. Folic acid is a B vitamin that helps the body make healthy new cells.

  • How do vitamin B12 and folic acid interact with each other?
  • A Study of the Prevalence of Serum Vitamin B12 and Folic Acid Deficiency in Western Maharashtra

Human body needs folic acid, especially those women who may get pregnant. Getting enough folic acid before and during pregnancy may prevent major birth defects of baby's brain or spine. It is also known as vitamin B9, folate, or folic acid. All B vitamins help the body to convert the food carbohydrates into fuel glucosewhich is used to produce energy.

These B vitamins, often referred to as B complex vitamins, help the body use fats and protein. B complex vitamins are needed for healthy skin, hair, eyes, and liver.

What Is the Relationship Between Folate & Vitamin B12?

Also, they help the nervous system function properly. Folic acid is the synthetic form of B9 which is found in supplements and fortified foods, while folate occurs naturally in foods. It helps in the production of DNA and RNA, the body's genetic material, especially when cells and tissues are growing rapidly, such as during infancy, adolescence, and pregnancy.

Folic acid works closely with vitamin B12 in making red blood cells and helps iron function properly in the body. Vitamin B9 works with vitamins B6 and B12 and other nutrients in controlling the blood levels of the amino acid homocysteine. High levels of homocysteine are associated with heart disease, although some researchers are not sure whether homocysteine is a cause of heart disease or just a marker that indicates the presence of heart disease.

The metabolic processes of folic acid and Vitamin B12 deficiency Mahmood L - J Health Res Rev

In addition, all grain and cereal products in the US are fortified with folic acid. These folic acid congeners are transported by receptor-mediated endocytosis across cells where they are needed to maintain normal erythropoiesis, interconvert amino acids, methylate tRNA, generate and use formate, and synthesize purine and thymidylate nucleic acids. Using vitamin B12 as a cofactor, folic acid can normalize high homocysteine levels by remethylation of homocysteine to methionine via methionine synthetase.

Since the body becomes deficient in folic acid, all cycles will become ineffective and lead to many problems such as megaloblastic anemia, cancer, and neural tube defects.

Serum vitamin B12 and folic acid levels of these patients were observed. Deficiency of vitamin B12 and folic acid was studied in 4 groups: Folic acid deficiency formed the major chunk of deficiency group. Six percent patients had neuropsychiatric manifestations.

b12 and folate relationship problems

Posterior column involvement viz. In a small study, it was found that megaloblastic anemia may have symptoms and signs referable to several systems including hematology, dermatology, gastrointestinal, neurology, and neuropsychiatry. Folic acid, hematological manifestations of folic acid deficiency, hematological manifestations of vitamin B12 deficiency, vitamin B12 Introduction Megaloblastic anemias are a heterogenous group of disorders that share common morphologic characteristics.

Erythrocytes are larger and have heavier nuclear-to-cytoplasmic ratios compared to normoblastic cells. Neutrophils can be hypersegmented, and megakaryocytes are abnormal. On the molecular level in the megaloblastic cells, the maturation of nuclei is delayed while cytoplasmic development is normal.